Current development in multicomponent catalytic synthesis of 1,5-benzodiazepines: A systematic review

نویسندگان

  • Akshdeep Sandhar Pharmaceutical Chemistry Division, Shivalik College of Pharmacy, (Under Local Govt. Deptt, Punjab) Nangal, Distt-Rupnagar, 140126, Punjab, India.
  • Manpreet Saini Pharmaceutical Chemistry Division, Shivalik College of Pharmacy, (Under Local Govt. Deptt, Punjab) Nangal, Distt-Rupnagar, 140126, Punjab, India.
  • Rajesh Singh Pharmaceutical Chemistry Division, Shivalik College of Pharmacy, (Under Local Govt. Deptt, Punjab) Nangal, Distt-Rupnagar, 140126, Punjab, India.
  • Sahil Kumar School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences and Technology, Baddi, Distt-Solan, 173205, Himachal Pradesh, India.
  • Shikha Sharma Pharmaceutical Chemistry Division, Shivalik College of Pharmacy, (Under Local Govt. Deptt, Punjab) Nangal, Distt-Rupnagar, 140126, Punjab, India.
چکیده مقاله:

1,5-benzodiazepines are regarded as one of the most important classes of heterocyclic compounds as privileged structures and have vast range of applications in the field of medicine and chemistry. They are therefore attractive synthetic targets for organic and medicinal chemist. The current review article mainly covers the multicomponent green chemistry approaches for the synthesis of 1,5-benzodiazepines. The review is organized systematically into types of catalysts used for the 1,5-benzodiazepines synthesis like silica supported catalysts, various Lewis acids, organoacids and miscellaneous catalysts. This article emphasizes on various heterogenous and homogenous catalysts used alongwith their yield and brief description of their mechanism of action. At the end of review, the entire catalysed are organized into tabulated form for quick at a glance review of various catalysts utilized with their yield and time taken for the synthesis.

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عنوان ژورنال

دوره 6  شماره 1

صفحات  1- 21

تاریخ انتشار 2016-03-01

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